Manchester United are able to include England midfielder Owen Hargreaves, who has been out with a knee problem.
Paul Scholes is out with a knee injury but Patrice Evra should play despite suffering a calf strain in midweek.
Man Utd (from): Van der Sar, Kuszczak, Brown, Ferdinand, Vidic, Pique, O'Shea, Evra, Fletcher, Ronaldo, Hargreaves, Anderson, Nani, Giggs, Rooney, Tevez, Eagles, Simpson
Manchester United manager Sir Alex Ferguson:
"It's been frustrating for Owen.
"Missing games is not what he came here for. He's come here for a big fee and he must be a bit disappointed.
"But it is a long season and he is back now which is terrific for us. It gives us a better chance of doing well."
BIG-MATCH FACTS
Manchester United and Middlesbrough clash for the 99th time in the league.
The Red Devils are out to follow up their impressive 4-2 Champions League win away to Dynamo Kiev, with an eighth straight league victory to jump over Arsenal and return to the top of the table.
United boast the Premier League's tightest defence with three goals shipped in 10 outings and an unparalleled seven clean sheets; 'Boro have conceded the opening goal in an unequalled eight of their 10 games in this division this term.
Boro have only lost once in six Premier League visits to Old Trafford since March 2002, winning two and drawing three.
CLUB FORM
MANCHESTER UNITED
Club stats
Fixtures
Highest achievable after Saturday's matches: 1st
Lowest could fall: 3rd
1. On the joint best current winning streak in the Premier League with Arsenal, of seven games. Not dropped a point since their only loss of the league campaign; 1-0, away to local rivals Manchester City on 19 August.
2. Dropped just seven points this term; Arsenal have dropped just two.
3. Conceded just one goal in claiming 21 points out of 21, and shipped one every 300 minutes (five hours) of Premier League football played, on average.
4. Scored four goals in each of the last two league outings; that total of eight is as many as accumulated in the previous 11.
5. On the longest current run in the Premier League of 13 matches since conceding more than a single goal in a game; the most recent being the 2-4 away win over Everton on 28 April.
6. Also on the longest current run in the Premier League of 50 matches since a defeat by more than a single goal; 3-0, away to Chelsea on 29 April 2006.
7. Their 10 league games have yielded the joint lowest number of goals; just 18 (15 for, three against). Only Chelsea also provide equally the least value for money in this regard.
8. One of seven clubs still holding an unbeaten home record in the Premier League.
9. The only side with a watertight home defensive record in the Premier League; yet to concede after five games at the Theatre of Dreams.
10. This match precedes next Saturday's top of the table showdown with Arsenal at the Emirates Stadium.
KEY PLAYER NOTES
MANCHESTER UNITED
RONALDO is Manchester United's top scorer with six goals.
RONALDO and Wayne ROONEY are the clubs top Premier League marksmen, with three each.
Ryan GIGGS is one short of 100 career league goals.
Patrice EVRA and Rio FERDINAND have been on the field for every minute of every one of Manchester United's Premier League matches this season.
If selected:-
Edwin VAN DER SAR will be keeping goal two days before turning 37.
If on the field from the outset:-
Chris EAGLES will be making his 50th English league start (Manchester United, Watford and Sheffield Wednesday).
Gary NEVILLE will be making his 350th Premier League start - all for the Red Devils.
HEAD TO HEAD
United were held to a 1-1 draw by a plucky Middlesbrough side in last season's corresponding fixture. The Red Devils have a 42% winning record against the Teessiders in the Premier League at Old Trafford (won just five of 12).
Home and away
League (inc PL): Man United 48 wins, Middlesbro 29, Draws 21
Prem: Man United 13 wins, Middlesbro 5, Draws 6
at Man United only
League (inc PL): Man United 28 wins, Middlesbro 11, Draws 10
Prem: Man United 5 wins, Middlesbro 3, Draws 4
LAST SEASON'S CORRESPONDING GAME
Manchester United 1-1 Middlesbrough
21 April 2007 - Ref: Peter Walton
Man United scorer: Richardson 3
Middlesbrough scorer: Viduka 45
REFEREE
Alan Wiley (Burntwood, Staffordshire)