Owen Hargreaves has been ruled out of Manchester United's Champions League tie at Sporting Lisbon on Wednesday.
The 26-year-old missed England's recent double-header and also United's Premier League win at Everton with a thigh strain and has still not yet recovered.
Wayne Rooney returns to the squad for the first time after fracturing his foot on the first day of the season.
John O'Shea, Darren Fletcher (both knee), Park Ji Sung and Ben Foster (ligament problems) are all out.
Defender Mikael Silvestre has been ruled out for the rest of the season after rupturing cruciate ligaments on Saturday.
Right-back Gary Neville is still short of full fitness after a calf strain.
Carlos Tevez, Anderson and former Sporting player Nani will get their first taste of Champions League action with the Red Devils.
Manchester United (from): Van der Sar, Kuszczak, Heaton, Brown, Vidic, Ferdinand, Pique, Evans, Evra, Ronaldo, Scholes, Carrick, Anderson, Nani, Gibson, Eagles, Martin, Giggs, Rooney, Tevez, Saha, Dong.
BIG MATCH STATS
Definitions of terms used:-
Champions League (CL) - only group phase matches and beyond of this competition which began in 1992-93.
Champions Cup/Champions League - all matches played since it began in 1955-56 including qualification matches.
European matches - all matches played in the major European tournaments (Fairs Cup, Uefa Cup, Cup Winners' Cup, Champions Cup, Champions League).
Uefa Super Cups, Intertoto Cups and the old Intercontinental Cup competition are excluded.
Sporting CP and Manchester United have met each other twice in European Cup football.
In the 1963-64 Cup Winners' Cup, Sporting eliminated the Old Trafford club in the quarter-finals. After United won their home leg 4-1, Sporting bounced back big by them United 5-0 in the return, and went on to win the Cup, their only European trophy ever.
Sporting CP beat MTK Budapest in the final of the 1963-64 Cup Winners' Cup. They are participating in the Champions League for the fourth time, and have never survived the group phase.
Manchester United have won the Champions Cup/Champions League twice (1968, 1999), the Cup Winners' Cup once (1991), the European Super Cup (1991) and the Intercontinental Club Cup (1999). They're about to embark on their 13th Champions League campaign, which makes them joint record holders with FC Porto. It is also their 12th successive CL campaign, which is the best streak ever.
Current European form
Sporting have not won any of their last five CL matches, losing the last two.
Manchester United have lost their last two CL away matches.
Player and disciplinary info
Carlos Paredes and Marat Izmailov are the most experienced CL players in the Sporting squad with 16 Champions League matches each. Derlei is the CL top scorer at Sporting with three career goals.
Gary Neville (98), Ryan Giggs (95) and Paul Scholes (95) are three Manchester United players that are ranked amongst the 10 players with most CL appearances. Giggs is the CL top scorer in Manchester United's squad with 23 CL goals.
Other miscellaneous facts
Manchester United are seeking their 100th victory in the Champions Cup/Champions League.
Sporting are in third place, three points behind leaders FC Porto in their domestic league; United are fourth in the Premier League, having taken 11 points from six matches