I've been thinking about this and my answer is yes, WHam and Wigan have nothing to play for one is mid table and nowhere near europe and the other is free from the championship for at least another season.
If we were to rest a couple of key players and lose 1-0 it would be worth it especially if we won against Barca.
If we were to rest a couple of key players and lose 1-0 it would be worth it especially if we won against Barca.